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Activated from the antibiotic rifampicin and various plant metabolites, including hyperforin, guggulipid, colupulone, and isoflavones. Response to certain ligands is species-precise. Activated by By natural means taking place steroids, including pregnenolone and progesterone. Binds into a reaction factor in the promoters of your CYP3A4 and ABCB1/MD